Lab Dosator

Lab Dosator is part of 3P innovation’s Pharma Equipment Discover Range, which fully replicates commercial dosator based powder dispensing, at a laboratory scale.

It can therefore screen pharmaceutical powder formulations for suitability with commercial machinery. It also automatically produces representative early phase clinical supplies.

The system can be configured to replicate the full range of dosators sizes (with or without pre-compression). Compared to manual filling with spatulas, the introduction of automation into laboratory applications reduces variability and enhances product quality.

Providing Flexibility

As a laboratory scale device this Dosator fits within small fume enclosures and operates with a very small powder bed. This is critical in the early stages of formulation and process development, when active ingredients may be scarce.

Another advantage to this Dosator is the micro dosing head version that is configured to present consistent powder samples in the 1mg to 5mg range.

Yet where this Dosator offers significant advantage is through its inherent flexibility and ability to replicate commercial processes. It can fill medical devices, inhalers, capsules or blisters under controlled laboratory conditions. The system dispenses consistent samples directly into delivery units for clinical or pharmaceutical evaluation.

Further optional enhancements include provision of bulk powder feeds to remove the need for manual powder bowl to-up, and integrated weighing head for 100 recording of all dispensed sample weights.

Supporting Quality by Design

Process understanding and Quality by Design relies on reliable process data. The Dosator provides users with live charting and recording of all critical process parameters. This includes pin height, powder bed height, pre-compression force, compression force and ejection force: dose weight is also available via an optional high speed weight cell.

Reducing time to market and process uncertainty

Understanding uncertainty and minimising risk early is key to reducing time to market. The Dosator ensures that scale issues are minimised by being compatible with industry standard dosating pin and tube sets. This ensures optimised product handling parameters can be developed from the outset and in the knowledge that the same parameters can then be applied to a scaled-up commercial manufacturing process.

Lowering clinical sample cost

The cost of supplying small scale clinical trials can be significant because the volumes do not justify commercial production processes. Alternatively, manually filling of capsules, blisters or tablet presses is not a cost-effective use of laboratory staff. The Dosator offers a cost-effective alternative. It can dispense powder precisely time after time, decreasing viability, lowering sample making costs and increasing the throughput of candidate drugs.

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Powder filling machine, lab fill2Weight helps customers significantly reduce drug development leadtimes: Fill2Weight handles very challenging powders, avoiding need for costly and time-consuming ‘formulation development’ which takes weeks and is traditionally needed to enable filling of powders with poor flow properties. We are supplying high quality powder filling machine in india since last 10+ years.

The world’s fastest, gravimetric powder micro-dosing technology has been designed to meet the increasing need for high-accuracy, precision powder filling in clean-room and sterile environments for inhalation, parenteral and oral solid dose (OSD) applications.

Fill2Weight is a scalable system that supports manufacture from clinical supply through to commercial production. The system is highly innovative as it combines several different technologies in one solution to get challenging powders to flow and dispense accurately.

Fill2Weight does not compact the powder unlike alternative filling technologies, which in turn increases the proportion of a drug that is able to have an active effect in inhalation applications. In addition, the very localised application of low-frequency vibration at the dispense point ensures that powder blends are not segregated or damaged.

Benefits summary:

•  High-speed, high-accuracy gravi-metric filling
•  For use in Aseptic environments
•  Suitable for spray dried and lyophilised powders
•  Slim-line design for unidirectional down flow applications
•  FDA approved materials
•  Autoclavable dispensing head
•  Tool-less disassembly for cleaning and sterilisation
•  Suitable for VHP environments

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