Howorth has considerable experience in supplying containment booths for a range of processes, including Pack-off systems.

 

 

The Pack-off system is designed to offer a primary level of containment when off-loading and packing off powdered products. The booth is providing an extra layer of protection to the operator (secondary containment) during the offloading/filling of drums, IBC, FIBC, and other containers.

Our extensive knowledge and expertise in the design of these systems ensure that we provide our clients with systems to suit even the most demanding specifications.

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Uni-Directional Air Flow (UDAF) Booths and Canopies provide a localised clean air environment of ISO 5 (Grade ‘A’) over an aseptic process. They are usually positioned above machines and pieces of equipment within cleanrooms or secure environments.

Aseptic isolators are routinely found within the pharmaceutical industry and are widely used for sterile injectable drug filling and sterile & pharmacy drug compounding. They are designed to provide continuous and complete isolation of the inside of the isolator from the external room environment (including its operators). This ensures that the environment is maintained as contamination-free to safeguard patients who will later be administered the drug.

Widely used for a number of applications including:

Sterility testing
Compounding
Sterile injectables
Pharmacy dispensing
Liquid filling
Aseptic transfer
Medical device manufacture and assembly
Packaging
Integration of key monitoring, processing and decontamination systems

 

For more than 150 years, the Howorth name has representedtechnical creativity and expertise in air engineering and its application to protect people and products from contamination.

Threat of contamination Human operators pose the greatest risk to product contamination during “conventional cleanroom” aseptic processing and manufacturing. Even under optimal conditions, a gowned, motionless human may generate 100,000 particles per ft3/min within a cleanroom, while a walking operator may generate 10,000,000 per ft3/min Using isolation systems minimizes the extent of personnel involvement and separates the external cleanroom environment from the aseptic processing line.

A positive pressure isolator or Restricted Access Barrier system (RABs), supported by adequate procedures for its maintenance, monitoring, and control, offers tangible advantages over classical aseptic cleanrooms, including fewer opportunities for microbial contamination during processing.

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API Isolators provide the highest levels of containment for handling toxic compounds. The manufacturing of Active and Highly Potent Active Pharmaceutical Ingredients (API and HPAPI) has become a growth area within the industry.

There is an ever increasing demand for higher containment, improved operator protection and equipment integration, as well as preventing cross-contamination within facilities.

Each isolator is a bespoke build to meet the client’s requirements and processes.

We can produce isolators to suit many different types of processes, here are just a few examples:

1. ADC Containment Isolators

2. Filter Dryer Isolators

3. Sampling & Dispensing Isolators

4. Reactor Charging Isolators

5. Fluid Bed Drying Isolators

6. Granulation & Milling Isolators

7. Compression Tablet Press & Encapsulation Isolators

8. Vacuum Tray Drying Isolators

9. BSL-4 Isolators

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Howorth is a market leader in providing innovative containment solutions.

Utilising our clean air engineering expertise, we can create safe and clean working environments for Pharmaceutical, Biological and Chemical organisations.

Our extensive knowledge and expertise in designing bespoke isolator systems to suit a variety of processes, ensures we provide our customers with solutions to suit even the most demanding requirements.

We have built a strong reputation within the industry for our innovative integration of process equipment within barrier isolation systems having successfully completed many equipment integration projects, both with end users and OEMs.

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Process Isolators are containment systems that allow the handling of toxic substances for various industries including pharmaceuticals.

Our high containment isolators provide advanced performance levels for both API and HPAPI, backed by a service that’s ultra-focused on your needs.

We work closely with you to gain an all round understanding of your requirements, evaluating ergonomic-related issues to improve isolator efficacy and improve operator protection.

Howorth has developed a wide range of innovative containment solutions for protecting personnel and the environment from potent pharmaceutical compounds. These solutions are carefully designed to ensure that they work in harmony with the core processes they are providing a barrier against. Dispensing and Sub-division For example, Howorth has developed an extensive number of isolator systems for use in the dispensing and sub-division of APIs and other compounds. Capable of nanogram levels of protection these systems incorporate features such as…

1. Single or multiple chambers
2. Fully interlocked air-locks, doors & visors
3. HEPA filtration on inlet & oulet vents
4. A number of transfer system options
5. Isolator raise/lower systems for operator comfort
6. Fully integrated & flush-mounted weigh scales
7. Automated or manual drum tippers

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Operators pose the greatest risk to product contamination during ‘conventional cleanroom’ aseptic processing.

Many different barriers of varying capabilities have been used to separate operators from critical sites during aseptic processing with the objective of reducing the probability of a contaminated unit.

These range from simple flexible curtains used on many traditional aseptic processing lines to advanced aseptic processing in isolators.

A Restricted Access Barrier System (RABS) is an advanced aseptic processing system that can be utilized in many applications in fill-finish and processing areas.

RABS provides an enclosed environment to reduce the risk of contamination to products, containers, closures, and product contact surfaces compared to the risks associated with conventional cleanroom operations.

RABS can operate as “doors closed” for processing with a very low risk of contamination similar to isolators or permit rare “open door interventions” provided appropriate measures are taken.

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Our BIOGEN Decontamination Systems can be effectively integrated into an ENVIROSAFE isolator, bringing more precision to protection in small volume enclosures such as safety cabinets, microbial incubators and glove box isolators. It efficiently disperses and extracts Hydrogen Peroxide vapor within the chamber, ensuring a better-protected environment.

Our BIOGEN decontamination technology can be fully integrated into an ENVIROSAFE isolator.

This cost-effective decontamination solution brings greater precision to protection in small volume enclosures such as safety cabinets, microbial incubators and glove box isolators.

BIOGEN Decontamination System manually draws up a developed amount of 33 to 35% Hydrogen Peroxide and disperses the vapor via an ultrasonic nozzle to fill the chamber. The cycle is completed once the vapour is extracted.

Next Generation – The Howorth BioGen Duo NGVHP Generator

Unlike earlier generation models, where H2O2 is vapourised by introducing it to a hotplate, the Next Generation BioGen design achieves this by ultrasonication, negating the requirement for system conditioning and with much faster dosing rates. Liquid H2O2 is transferred at 100ml/min to the ultrasonic generator, where it is converted to VHP at <3µ.

There is no need to dehumidify the room or chamber as this system can operate at up to 95% RH. Unlike the second generation example, there is also no need for complicated valving to change from gassing to aeration loops, with a simple switchover so that the catalyst draws VHP/air from the decontamination area to break down H2O2 into water and oxygen.

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High Containment Screens are a simple yet effective way of boosting the containment capabilities of any Downflow Booth.

With our latest range of screens, we are able to offer previously unattainable levels of operator protection. The 5D Screen has been designed to enhance the comfort of operators while the range of movement helps to prevent bad practices during operations.

Independent testing has confirmed that OEL’s as low as 1 ug/m3 8 Hours TWA can be achieved. This means that for operations where an air suit or isolator were previously the only option, a Downflow Booth combined with a High Containment Screen is now a viable solution.

Drum and Solvent Handling Booths are designed to control vapours and aerosols that are created during the transfer of solvents and liquids and other handling processes i.e. drum to drum transfer or drum to process reaction vessel.

Protecting surrounding environments against hazardous vapours and aerosols, Drum and Solvent Handling Booths safeguard both the operator and the room environment during all reactions, distillations, and general wet chemistry experimental work.

These booths are typically employed in kilo, pilot and developmental wet chemistry labs.

Our equipment can also be designed to satisfy the requirements of REACH.